Mechanisms of protein misfolding: Novel therapeutic approaches to protein-misfolding diseases
نویسندگان
چکیده
منابع مشابه
Protein-misfolding diseases and chaperone-based therapeutic approaches.
A large number of neurodegenerative diseases in humans result from protein misfolding and aggregation. Protein misfolding is believed to be the primary cause of Alzheimer's disease, Parkinson's disease, Huntington's disease, Creutzfeldt-Jakob disease, cystic fibrosis, Gaucher's disease and many other degenerative and neurodegenerative disorders. Cellular molecular chaperones, which are ubiquito...
متن کاملProtein misfolding diseases
Protein misfolding diseases include highly debilitating degenerative disorders like Alzheimer’s and Parkinson’s diseases [1]. The healthcare and financial burden linked to these pathologies has been steadily increasing over the past decade [2]. Actually, there is currently no efficient treatment for misfolding diseases as well as no reliable early diagnostic techniques for them [3]. It is known...
متن کاملProtein Misfolding Diseases.
The majority of protein molecules must fold into defined three-dimensional structures to acquire functional activity. However, protein chains can adopt a multitude of conformational states, and their biologically active conformation is often only marginally stable. Metastable proteins tend to populate misfolded species that are prone to forming toxic aggregates, including soluble oligomers and ...
متن کاملProtein Misfolding Diseases
Diseases caused by protein misfolding are an emerging pathologic category that are thought to share some basic common mechanisms and display impressive heterogeneity in terms of tissue involvement, age of onset and clinical features. The growing recognition of the impact that protein misfolding has on human diseases is certainly related to the phenomenon of population aging and the expansion of...
متن کاملProtein Misfolding and Neurodegenerative Diseases
This special issue includes fifteen reviews and two original research articles by leading scientists in the fields of neu-ropathology, biochemistry, and cell biology, dealing with the role of protein aggregation and prion-like propagation of protein misfolding in neurodegenerative diseases. In the review article " Breaking the code of amyloid-í µí»½ oli-gomers, " available at the following link...
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ژورنال
عنوان ژورنال: Journal of Molecular Structure
سال: 2016
ISSN: 0022-2860
DOI: 10.1016/j.molstruc.2016.06.046